Slides and video from my exit seminar [Link] →
Over on my ACGT blog, I've included slides and videos from my exit seminar today at UC Davis. I enjoyed the opportunity to say goodbye in an informal and (hopefully) entertaining presentation.
Over on my ACGT blog, I've included slides and videos from my exit seminar today at UC Davis. I enjoyed the opportunity to say goodbye in an informal and (hopefully) entertaining presentation.
The UC Davis Genome and Biomedical Sciences Facility, home to the Genome Center.
Next week is my last week at the UC Davis Genome Center. After almost 11 years, I will be saying goodbye as our family makes plans to return to the UK at the end of December. I will be giving a highly informal, and hopefully entertaining, exit seminar…the title is as follows:
Assemblathon to Zykovich: an A-Z that reflects a decade at the UC Davis Genome Center
All are welcome. There will be cakes!
Friday 20th November, 10:00 am in the GBSF auditorium (room 1005)
Image from flickr user chunkysalsa
This week I turned 44. It struck me that this number is the same as the total number of American presidents, and this got me thinking about a few things:
I will define this metric — the number of times that your age matches the number of the current president as the POTUS Number Number (PNN). Here are some observations about PNNs that try to answer the above questions:
The first people to ever achieve a PNN of 1 would have been those who turned 1 year old at any time beween April 30th, 1789 and March 4, 1797.
People who turned one year old at any point in the last year of George Washington's presidency would — assuming they continued to live — have then been two years old during some stage of the presidency of POTUS #2. These people would therefore be the first to experience matching their POTUS number twice, i.e. gaining a PNN of 2. More generally, anyone who celebrates gaining their first PNN point in the last year of a presidency, has a good chance of gaining a second PNN point. For example, barring any bizarre gardening accidents, I will be 45 when POTUS #45 takes office on January 20, 2017. This will increment my PNN from 1 to 2.
Presidential inaugurations mark the handover of power between two presidents on a single day. Over the course of history, presidential inaugurations have happened on five different calendar dates. Before the Twentieth Amendment to the United States Constitution, inaugurations mostly took place on March 4, but since then they mostly take place on January 20. Some exceptions have been when the inauguration would fall on a Sunday, in which case it is pushed back one day.
This means, that March 4 and January 20 have probably been the days on which the most PNN points have been awarded. For example, the 2009 inauguration (on January 20) meant that that people who were turning 43 or 44 on that day could both gain a PNN point.
For a chance of advancing beyond a PNN of 2, someone would need a sitting president to serve a shorter than usual term. The president in question would also have to depart office within a year of assuming the presidency.
POTUS #9 died in office after just one month. This means that someone who turned 8 years old between March 4 and April 4, 1840 (PNN = 1) would have turned 9 during POTUS #9's ill-fated tenure in 1841 (PNN = 2), and would then have turned 10 while POTUS #10 was still in office (PNN = 3).
POTUS #20 is the only other president to serve for less than a year, and as he passed away in 1881, it means that there is no-one alive today who can still be a member of the very exclusive 'PNN = 3' club.
Since the passing of the Twenty-second Amendment to the Constitution, presidents can only serve two terms in office, limiting a president to four or eight years in office (the latter occurring when a president seeks, and secures, re-election).
This amendment was introduced after the death of POTUS #32 who served as president for over 12 years. As you have the best chance of securing a 2nd PNN point if you achieve your first PNN point in the penultimate year of a presidency, FDR's long rule meant that it decreased the options for 32 year olds seeking an additional PNN point.
Now we can turn to the important question of whether any sitting president ever achieved a PNN. As we are currently at POTUS #44, you might think this would be unlikely…and you would be correct. There have only been two presidents who took office when they were younger than 44. POTUS #26 was 42 and POTUS #35 was 43.
The closest we have come to this situation is with the current POTUS (#44), who was 47 when he took office, giving us a PNN differential of 3. POTUS #42 was the next closest with a PNN differential of 4 (he took office at the age of 46).
However, as the POTUS number continues to increase, we will surely see a sitting president gain a PNN in the near future. It could happen as soon as 2017 as there are three candidates seeking to secure the Republican Party nomination who are all aged 44 (Ted Cruz, Marco Rubio, and Bobby Jindal). However, Ted Cruz will be 45 on December 22, 2015; this means that — should he be elected President — he will miss the chance of gaining a POTUS PNN by just under a month. Given Bobby Jindal's recent polling numbers, only Marco Rubio has any sort of realistic chance of becoming POTUS #45 at age 45 (with the added benefit of joining the PNN=2 club).
Obviously there were no PNNs to be gained before America elected their first president. This made me wonder whether one day the POTUS number will get so high that no-one will be able to gain any new PNN points, i.e. when POTUS number > average life expectancy.
The average term of office since the inauguration of POTUS #34 in 1953 is about 6 years. So we can forecast that by the year 2100, we may see the election of POTUS #59 (assuming that term limits do not change and that America, and its presidential system of government, endures).
Life expectancy will surely increase over that period as well. The average American born today has a life expectancy of about 79 years. This is just a little higher than the age of POTUS #40 when he became the oldest president to leave office at the age of 77. The UN's World Population Prospects report predicts that by 2100, average life expectancy of Americans might rise to about 88 or 91 (male and female respectively).
Based on these numbers it seens that there will be plenty of PNNs to be gained in the foreseeable future. My two-year old son may have to wait until the year 2064 or so though before he can gain his first PNN, when POTUS #53 will be in office.
Some may know it as the UC Davis Social Sciences and Humanities Building, but for me it will always be the Death Star. It's an amazing building…well technically it is a collection of many interconncted buildings, all packed with awkward, imposing angles. It is very easy to get lost in the innards and courtyards of this building, and this (intentional) design feature is part of the charm.
No two corners (or windows) appear to be the same and there are many steps that lead you to dark nooks and crannies. Perfect spots for plotting the destruction of those Rebel scum.
If you have never visited the Death Star, then you should give yourself to the Dark Side (at least once!). Here are some black and white photos that depict the Death Star in all of its raw and powerful beauty.
Click on the pictures to enlarge…
I tweet a lot and I write a lot on my blogs, especially on my ACGT blog. Sometimes I write things where I think: This…this is the one that will go viral. And of course it never happens that way. The more I try to engineer a meme, the less likely the chance of success seems to be. This is why my concept of a #MexicanTweetOff never went anywhere, and that no-one seemed to get the joke in my recent #IamSpartacash tweet:
"Hello, I'm Johnny Cash"
"No, I am Johnny Cash"
"No…I'm Johnny Cash"
#IamSpartacash pic.twitter.com/Z0n7seqSeJ
— Keith Bradnam (@kbradnam) August 28, 2015
But then there are those tweets and blog posts which I think won't be of that much interest to anyone, but turn out to be the most popular things I've ever written. This week has been surprising in that two of my social media posts have taken on a life of their own.
First, I spotted the opportunity to have a bit of fun with Genomics England. Last Thursday was a big news day for them with the project being featured in Nature. So after seeing the piece in Nature early on Thursday morning, I came up with this:
Excited to announce my new company: 'Gnomics England'. We will be sequencing the genomes of 100,000 gnome owners. pic.twitter.com/Tjpi5PQg0R
— Keith Bradnam (@kbradnam) August 27, 2015
This tweet went on to have over 40 retweets and Genomics England ended up featuring me in a storify article on Friday about their news of the previous day. To date, that tweet has reached an audience of over 67,000 people on twitter!
Then on Friday I was trying to find an image to use in a talk. I wanted to make a point about Excel often being an inappropriate tool for the management/querying of biological data, and just wanted a picture of Excel containing some sort of biological data. I was quite surprised by the image that I eventually found, and immediately shared it in a quick blog post:
Admittedly. the 'NFSW' part of the blog post title was a tactic designed to deliberately provoke curiosity. I tweeted about the blog post on Friday afternoon, a time which normally doesn't provoke a lot of interest (many of my European followers will have gone to bed by this point).
But it seems that this post hit a nerve and it has subsequently taken on a life of its own. Currently, there has been 64 retweets and 44 favorites, and now it is being spread on Facebook. By the end of Friday, it had become the most read item on my blog for the entire week (this never happens for posts I publish on Friday afternoons). I assumed that traffic would die down on Saturday but that didn't happen. By the end of Saturday, the post was my most read article of anything I have posted in the last 4 months.
At this point I assumed that things would surely quiet down on Sunday, but that didn't happen either. Traffic to my blog doubled compared to Saturday, and the post has now become the most viewed article of anything I have written in 2015, with almost 3x the page views compared to the next most-read article.
I guess the message here is that I should stop trying to predict the popularity of my social media posts!
Liftoff is a new podcast on the Relay FM network that has a delightful theme tune written by Chris Breen. The subject matter of this podcast is 'space, the universe, and everthing'.
If you listen to episode 1 of the podcast, you will only hear about 20 seconds of the beautiful theme music, and only 8 seconds without any spoken interference. This is a great shame because Chris Breen recorded a full minute of music. It is delicate, quiet, and yet expansive and deep. It is therefore perfectly suited for its subject matter. Chris — who has written many podcast themes — provides some insight into how he wrote the theme on his blog and provides a link to where you can download the music (titled Space Theme).
I found myself listening to this piece over and over again. As Chris notes in his post, this is not your typical podcast theme. In my opinion, the most amazing thing about it is the level of restraint that Chris has wielded. It would be so easy to maybe overdub a ringing electric guitar solo, or add all manner of additional tracks to fill out some of the 'space' in the music.
After I had listened to the track for a day or two, I found myself wanting more. So I took it upon myself to make a remixed version of the theme. The main reason was just to give myself more of this lovely music. So using GarageBand, I made some edits to effectively double the length of the track. Because the track has a natural ending point, I had to duplicate material just before the end, and play around to find a natural cutting point.
At this point, I felt the new second half of the song needed something extra to help build the song just a little bit more. This gave me the opportunity to add a few bars of 'Breathy Vox' to partly mask the join I had made. I then added some simple strings and a few other effects. When I saw that GarageBand had a synth sound called 'Sea of Tranquility', I felt that this had to be added.
I tried various other additions, at one point adding a quite sweet clarinet track, but I kept on coming back to the restraint that Chris had shown and felt that I had to honor that as much as possible. The screenshot below shows my final set of additions and edits in GarageBand (click to enlarge):
You can hear my version here. Thank you Chris for making a truly beautiful piece of music. I hope that the Liftoff podcast can do it more justice in future episodes!
Just a quick note to say that I am currently writing a new book with the help of Michelle Gill and Ian Korf. This will be a follow up our Unix and Perl to the Rescue! book. The name?
Unix and Python to the Rescue!
Snazzy eh? You can find out more details about why we are doing this on the newly revamped Rescued by code! website (it didn't make sense to keep on using the unixandperl.com website anymore).
The Take-Home Message
Today I helped launch the Take-Home Message, a new bi-weekly web comic that aims to entertain and inform its readers about various aspects of biology, genomics, and bioinformatics. The comic is drawn by the very talented Abby Yu, and you can read a little more about how and why it was launched on my ACGT blog.
At the time of writing, it's been just over 8 hours since we made the Take-Home Message official. How has the launch gone?
Overall, I'm extremely pleased by this. It will be interesting to see how well comic #2 does when it goes live in a couple of weeks. Thanks to everyone for their kind words about the comic and the website.
Yesterday was flag day in the United States. So it seems a fitting time to launch my idea for a flag for the city of Davis, California. Davis currently has a logo, which incorporates a Penny Farthing bicycle, but this is not a good choice for a flag as it breaks many rules of good flag design.
Here is my proposed design (you can also download a larger version without the border):
The video below explains what this design symbolizes. I shall contact the Davis City Council with my idea, but I would love it if they organized a proper flag designing competition, open to all residents of Davis.
Flags can be rallying symbols that a city can unite behind. Flags can also give people a sense of pride about where they live. So let's have a flag for Davis, California!
I was recently interviewed by Front Line Genomics to talk about my life in bioinformatics. The interview initially appeared in their magazine (PDF available) but is now on their regular website too:
A big thanks to Carl Smith for his many kind words, and for asking me to be interviewed.
I recently launched a new blog, These go to five, which is attempting to (very slowly) chronicle all of the five-star songs that make up my iTunes music library. These songs represent only about 1% of my ~13,000 song music collection, so I thought I would use the blog to explain why they are so special to me.
Once I had settled on the name — a bit of an oblique reference to these go to eleven — I then started work on my design for a banner logo. The following video shows how I iterated over several designs before arriving at the final version. The backing music is an instrumental song that I wrote as part of the RPM music challenge.
Time for some amateur psephology regarding the imminent UK general election. British voters have probably seen many, many graphs like this one which shows the projected share of the vote:
Data from electionforecast.co.uk
However, these type of graphs don't always reflect the picture among the entire electorate. That's because a sizable chunk of eligible voters do not vote. In the previous 2010 election, voter turnout was 65.1% and this is pretty close to the average from the last four elections (average turnout 64.1%). So let's assume that turnout on Thursday will be about the same, and I'll arbitrarily set it at 65%. This means that the 34.5% of people who are projected to vote Conservative are really drawn from the 65% of people who might actually vote. I.e. the percentage of the electorate who might vote Conservative is only 22.4%. So the most popular party — in terms of share of the vote — may only have the backing of fewer than 1-in-4 possible voters. Let's see how things look if we plot the support for each party based on the percentage of the electorate who might vote for them:
Of course, it's possible that the third or so of people who don't vote may all have strong leanings towards the Conservatives, or towards Labour, or it may be that the 35% contains a representative mix of supporters of all of the parties. I'm not sure if anyone has any good insight into political allegiances of this group of non-voters.
There is already a lot of speculation as to which coalition might end up coming together to form a workable government (there are a lot of permutations). So I'm curious about how well possible coalitions might reflect support from the electorate as a whole vs the combined number of seats they would amass as a voting block. To gain an absolute majority, any coalition would ideally need 325 of the 650 seats.
The following graph plots the number of seats that various Conservative and Labour coalitions might achieve vs the possible percentage of the electorate that might back such a coalition. I've also included separate data points for Conservative and Labour as potential minority governments (circles and squares indicate Conservative/Labour coalitions respectively):
So what does all of this mean? First let's look at the situation for the Conservatives:
And for Labour:
So in the unlikely scenario of grand Conservative or Labour coalitions, you still end up with a situation where less than 40% of the electorate would have voted for them. Only if Labour can unite with the SNP, will they have a chance of an absolute majority (>325 seats). The best they can do otherwise might be about 300 seats or so.
I find it interesting that the slice of the electorate who probably won't vote is larger than any single party, and larger than all of the potential coalitions listed above bar one (the grand Conservative coalition).
Whatever happens on Thursday — and over the following days and weeks — it will probably be true that any resulting coalition is going to be unpopular with most of the electorate.
Image from http://flickr.com/photos/jeepersmedia/
A few months ago I received an email inviting me to give a talk at a company that will remain anonymous — let's just say that it is a Bay Area company that has an interest in genomics (so that narrows it down to a few hundred or so).
I will stress that the original email simply asked, in very general terms, if I would be interested in visiting to give a talk. There was some back-and-forth email as we tried confirming a date and one email clarified that I could give a talk, have lunch, and then "perhaps" have some one-on-one meetings.
After we confirmed the date, I received an email that included my itinerary for the day. A few alarm bells rang when I saw that the file attachment was named 'Interview schedule'. In addition to giving a talk and having lunch I was now scheduled to have seven separate interviews with people at the company.
At this point I noticed from their company's website that they were actively recruiting, but I double checked all of our earlier email communications and confirmed that at no point had any employment opportunities been mentioned. So maybe 'interviews' was their name for informal one-on-ones?
Then a few days ago I received another confusing email that asked me to sign the company's NDA and complete the the employment application form. Hmm, it was decidedly looking like they were under the impression that I was being interviewed for a job. Not wanting to waste anyone's time I clarified that I thought I was just giving a talk. This no doubt has caused an equal measure of confusion at their end, and they swiftly suggested we cancel the whole thing.
So I'm no longer giving a talk this week, though as I have made many new slides I may well put the talk online anyway. It still kind of amazes me that this company could get so far along the recruitment process without realizing that the person that they wanted to interview hadn't actually applied for anything.
There is a relatively new Japanese restaurant in Davis. Like all restaurants, and most places of business, it has signage that displays the name of the restaurant. Here is how that sign looks when looking at it directly from about 20 feet away:
If you were driving past this establishment, you'd be another 20 feet or so away from the sign. I suspect that many of you might not be able to clearly read the first word. Here's a close up:
The shadows that you can see hint at the problem that I'm about to raise. This signage is 3-dimensional, with the letters being raised several inches from the wall. So what happens when you have such a sign and you try looking at it from anything other than directly head on?
Doesn't seem great from a marketing perspective if the name of your business can only be read when looking at your sign from one particular angle! It's a little better at night as the white backing to the letters is illuminated. Here is a close up that more clearly shows the 3-dimensional nature of the sign:
Did no-one check this at any point and ask the simple question "Wait, can you actually read those words?"
There really is an awful lot of pointless rubbish on change.org. So I was curious whether they would let me create a petition calling for change to change.org. Specifically, to stop all of these pointless petitions from being added in the first place.
The fact that they allowed me to create such a petition perfectly illustrate my case regarding a need for some sort of curation. My petition is now live:
Join with me and together we can rule the Galaxy as father and son…er, I mean we can make a difference. In the immortal words of Mr. David Robert Jones: "Time to make a change".
This weekend we managed to catch the Sketches of Science exhibition at the Mondavi Center (also see the official website). I thoroughly recommend that people catch this free exhibition before it finishes on 28th January.
Photographer Volker Steger has met with many Nobel prize winners and asked them to make a poster (using crayons) that represents their nobel-prize-winning science. He then photographs them with their poster and some of the posters are also accompanied by audio interviews.
There is a lot of humor, beauty, and fun that emerges from this experience. Some scientists go for a simple representation of their work, others pack a lot into the poster (including a poem in one instance). Well worth seeing if you get a chance. I believe that this is the only place in the USA where this exhibit is being shown at the moment.
Martie Chalfie, one of many folks to win the nobel prize for their work on Caenorhabditis elegans
Bob Horvitz, another C. elegans researcher to feature in the exhibition
This Saturday marked by 10th year at UC Davis (also my 10th year of living in the USA). This is kind of incredible since the plan was only ever to stay for a year or two! Since arriving here in 2005, I have become a husband, a father, and settled down to a wonderful family life.
However, all good things come to an end and so we are planning to move back across the pond. We don't yet know where we will go (probably the UK, but possibly Western Europe), we don't know yet know what we we will do (probably something related to science), and we don't yet know when we will go (probably early 2016).
The USA, and Davis in particuar, has been very good to us both professionally and personally. Our careers have flourished, but more importantly we have made some wonderful friends who we expect to keep in close contact with wherever we end up.
I thought that this would be a fitting time to relaunch my website and blog as I plan to write more regarding what will be the next big chapter in our lives. The idea of not knowing where you will be in a year's time, or what you will be doing, is exciting and scary in equal measure.
I'm looking forward to what the future brings us.
I've decided that as I'm increasingly using this blog to write about science-related topics (bioinformatics in particular), that they should have a new home. Therefore, all of my existing genomics and bioinformatics blog posts have been copied to my new ACGT blog:
I have also removed these posts from this site so that (ultimately) they will only show up in one place in search engine results. Going forward, I will use the ACGT blog to write about anything that is predominantly science related. In contrast, this blog will now be used almost exclusively for stuff that is not primarily related to my research work.
Updated 2015-11-12 to reflect that I have now removed the posts that were duplicated between this blog and ACGT.
A few days ago, UC Davis student Joe Na (@joenagraphy on twitter) released this hyperlapse video of scenes from around the UC Davis campus, and I've found myself captivated by it.
UC Davis from Joseph Na on Vimeo.
One reason why I've been watching this video over and over again is because Joe has shot some superb scenes with amazing lighting, and it is just beautiful to watch. However, that's not the only reason why I'm so drawn to this video.
After nine years of working at UC Davis I realized just how connected I feel to many of the places that are included in this video. For most of the last two years I have abandoned cycling in favor of walking everywhere on campus. I'm based on the 'far side' of campus near Aggie Stadium, but frequent meetings, teaching requirements, and the need to get a bus home, all mean that I'm regularly walking all over campus.
When I first saw this video, I instantly recognized every location because in an average week, I walk past (or through) most of them! So here is my shot-by-shot breakdown of the video (with links to DavisWiki as appropriate):
Thanks again to Joe for making a beautiful video which serves as a wonderful advertisment for UC Davis.
I thought I would group together links to my set of six posts about how I have migrated from Gmail to FastMail: